Studies

Published Studies.

First Author Disease Gene/Mutation Species Year Reprogramming Starting Cell Type Generated Cell Type Number of Disease Patients Number of Control Patients Utilization of Gene-Editing or Isogenetic Cell Lines GEO ID Platform Name Platform GEO PMID
Muratore Alzheimer's Disease APP/ V717I Homo sapiens 2014 Lentiviruses encoding Oct4, SOX2, c-MYC and KLF4 Fibroblast Neurons 2 4 False 24524897
Sproul Alzheimer's Disease PSEN1/ A246E Homo sapiens 2014 Oct4, KLF4, Sox2, and c-Myc retroviruses Fibroblast NSCs 4 1 False 24416243
Koch Alzheimer's Disease PSEN1/ L166P Homo sapiens 2012 Lentiviral Backbone (1-α (EF1α) promoter and IRES) Fibroblast Neurons 1 1 False 22510327
Isreal Alzheimer's Disease APP/ Duplication Homo sapiens 2012 MMLV vectors containing the complementary DNAs for OCT4, SOX2, KLF4, c-MYC and ± EGFP Fibroblast Neurons 2 2 False 22278060
Schöndorf Parkinson's Disease GBA1/ L444P, GBA1/ N370S Homo sapiens 2014 Retroviruses encoding OCT4,SOX2, KLF4 and c-MYC Fibroblast Neurons 4 2 False 24905578
Nguyen Parkinson's Disease LRRK2/ G2019S Homo sapiens 2011 Retroviruses of OCT4, SOX2, and KLF4 Fibroblast Neurons 1 1 False 21362567
Sanders Parkinson's Disease LRRK2/ G2019S, LRRK2/R1441C Homo sapiens 2013 Retroviruses of OCT4, SOX2, KLF4 and CMYC Fibroblast NSCs 5, 3 3 False 24148854
Sánchez-Danés Parkinson's Disease LRRK2/ G2019S Homo sapiens 2012 Retroviruses encoding FLAG-tagged OCT4, SOX2 and KLF4 Fibroblast Neurons 4 4 False 22407749
Cooper Parkinson's Disease LRRK2/ G2019S, LRRK2/R1441C, PINK1/ Q456X Homo sapiens 2012 Retroviruses of OCT4, SOX2, KLF4 and c-MYC Fibroblast Neurons 3, 2, 2 2 False 22764206
Reyes Parkinson's Disease SNCA/ Triplication Homo sapiens 2014 Retroviruses of Oct4, Sox2, c-Myc, Klf4 Fibroblast Neurons 3 1 False 25046995
Byers Parkinson's Disease SNCA/ Triplication Homo sapiens 2011 Retroviral gene insertion of OCT4, SOX2, KLF4, and c-MYC Fibroblast Neurons 1 1 False 22110584
Chung Parkinson's Disease SNCA/ Triplication Homo sapiens 2013 Cre-excisable polycistronic lentivirus encoding SOX2, KLF4, OCT4 and c-MYC Fibroblast Neurons 1 1 False 24158904
Imaizumi Parkinson's Disease Parkin/ Deletions on exons 3 and 5 Homo sapiens 2012 Retroviruses carrying Oct4, Sox2, Klf4, and c-Myc Fibroblast Neurons 2 2 False 23039195
Rakovic Parkinson's Disease PINK1/ Q456X Homo sapiens 2012 Retroviral pMIG vectors OCT4, SOX2, cMYC and KLF4 Fibroblast Neurons 2 1 False 23212910
Seibler Parkinson's Disease PINK1/ Q456X, PINK1/ V170G Homo sapiens 2011 Retroviral pMIG vectors OCT4, SOX2, cMYC and KLF4 Fibroblast Neurons 3 1 False 21508222
Xia Dystrophia Myotonica type 1 DMPK/ CTG repeats Homo sapiens 2013 Retroviral transduction of hOct4, hSox2, hKlf4, and hc-Myc Fibroblast Neurons, NSCs, Astrocytes, iPSCs 2 1 False 23550732
Chang Spinal Muscular Atrophy SMN1/ not specified Homo sapiens 2011 Retroviral vectors containing Oct4, Sox2, c-Myc, Klf4 Fibroblast Neurons 1 1 False 21956898
Sareen Spinal Muscular Atrophy SMN1/ not specified Homo sapiens 2012 Lentiviral infection of primers for OCT 4, SOX 2, NANOG, LIN 28, HoxB4, SMN, and GAPDH Fibroblast Neurons 2 1 False 22723941
Kim Rett Syndrome MeCP2/ Q244X Homo sapiens 2011 pMIG retrovirus expressing OCT4, SOX2, KLF4, and MYC Fibroblast Neurons, NSCs, iPSCs 5 5 False 21807996
Ricciardi Rett Syndrome CDKL5/ R59X, CDKL5/ L220P Homo sapiens 2012 Retrovirus infection of OCT4, SOX2   and KLF4 Fibroblast Neurons 2, 2 2 False 22922712
Cheung Rett Syndrome MeCP2/ deletions on exons 3 and 4, MeCP2/ T158M, MeCP2/ R306C, Homo sapiens 2011 Lentiviral infection with EOS-vector and MoMLV-based retroviral vectors encoding OCT4, SOX2, KLF4 and c-MYC Fibroblast iPSCs 1,3,3 1,1,1 True 21372149
Koch Spinocerebellar Ataxia Type 3 ATXN3/ CAG repeats Homo sapiens 2011 Retroviral plasmids for OCT4, SOX2, KLF4 and c-MYC Fibroblast Neurons 1 2 False 22113611
Almeida Frontotemporal dementia/ Amyotrophic lateral sclerosis C9ORF72/ GGGGCC repeats Homo sapiens 2013 Retroviruses expressing human OCT3/4, SOX2, KLF4, and c-MYC Fibroblast Neurons 2 1 False 23836290
Bilican Amyotrophic lateral sclerosis TDP-43/ M337V Homo sapiens 2012 Retroviral pMIG vectors OCT4, SOX2, cMYC and KLF4 Fibroblast Neurons 1 2 False 22451909
Egawa Amyotrophic lateral sclerosis TDP-43/ M337V, TDP-43/ Q343R, TDP-43/ G298S Homo sapiens 2012 Retrovirus of Sox2, Klf4, Oct3/4, and/or c-Myc or episomal vectors of Sox2, Klf4, Oct3/4, L-Myc, Lin28, and short hairpin RNA for p53 Fibroblast Neurons 3, 3, 3 5 False 22855461
Serio Amyotrophic lateral sclerosis TDP-43/ M337V Homo sapiens 2013 Retroviruses encoding Oct4, Sox2, Klf4 and Myc Fibroblast Astrocytes 1 2 False 23401527
Chen Amyotrophic lateral sclerosis SOD1/ D90A, SOD1/ A4V Homo sapiens 2014 Nonintegrating Sendai virus of OCT4, SOX2, KLF4 and c-MYC, Retroviral plasmids for OCT4, SOX2, KLF4 and c-MYC Fibroblast Neurons 1, 1 2 False 24704493
Zhang Huntington's Disease HTT/ CAG repeats Homo sapiens 2010 VSVg retroviruses of Sox2, Klf4, Oct3/4, and/or c-Myc Fibroblast NSCs 1 1 False 21037797
Jeon Huntington's Disease HTT/ CAG repeats Homo sapiens 2012 VSVg retroviruses of Sox2, Klf4, Oct3/4, and/or c-Myc Fibroblast iPSCs 1 3 False 22628015
Juopperi Huntington's Disease HTT/ CAG repeats Homo sapiens 2012 Retroviral transduction of Oct3/4, Sox2, c-MYC and Klf4 Fibroblast Astrocytes 2 1 False 22613578
Chae Huntington's Disease HTT/ CAG repeats Homo sapiens 2012 VSVg retroviruses of Sox2, Klf4, Oct3/4, and/or c-Myc Fibroblast iPSCs 2 2 False 22694310
Guo Huntington's Disease HTT/ CAG repeats Homo sapiens 2013  VSV-g pseudotyped hSTEMCCA lentivirus containing a polycistronic coding sequence for Sox2, Klf4, Oct3/4, and/or c-Myc Fibroblast Neurons 2 2 False 24231356
Jang X-linked adrenoleukodystrophy ABCD1 or ALDP/AMN patient, ABCD1 or ALDP/ CCALD patient Homo sapiens 2011 Retroviral plasmids for OCT4, SOX2, KLF4 and c-MYC Fibroblast Neurons, Oligodendrocytes 1, 1 1 False 21721033
Liu Dravet Syndrome SCN1A/ IVS14+3A>T Homo sapiens 2013 Retroviral infection of pMXs-Oct3/4, pMXs-Sox2, pMXs-Klf4, pMXs-c-Myc Fibroblast Neurons 2 3 False 23821540
Higurashi Dravet Syndrome SCN1A/ mutation on 4933C>T Homo sapiens 2013 Retroviral plasmids for OCT4, SOX2, KLF4 and c-MYC Fibroblast Neurons 1 1 False 23639079
Hick Friedreich's Ataxia FXN/ expanded GAA repeats Homo sapiens 2012  Lentivirus factors OCT4, SOX2, LIN28 and NANOG  Fibroblast Neurons, iPSCs 2 2 False 23136396
Fong Tauopathies MAPT/ A152T Homo sapiens 2013 Retroviral plasmids for OCT4, SOX2, KLF4 and c-MYC Fibroblast Neurons 1 1 True 24319659
Numasawa-Kuroiwa Pelizaeus-Merzbacher disease PLP1/ missense Homo sapiens 2014 Retroviral plasmids for OCT4, SOX2, KLF4 and c-MYC Fibroblast Oligodendrocytes 2 2 False 24936452
Doers Fragile X Syndrome FMR1/ CGG repeats Homo sapiens 2014 Retroviral transduction of Oct3/4, Sox2, c-MYC and Klf4 Fibroblast Neurons 3 1 True 24654675
Sheridan Fragile X Syndrome FMR1/ CGG repeats Homo sapiens 2011 Retroviral pMIG vectors OCT4, SOX2, cMYC and KLF4 Fibroblast Neurons 3 2 False 22022567
Suh Menkes Disease ATP7A/ c4005 + G > A Homo sapiens 2014 Retroviral transduction of Oct3/4, Sox2, c-MYC and Klf4 Fibroblast iPSCs 1 1 False 24468087
Higuchi Pompe Disease GAA/ not specified Homo sapiens 2014 pMX retrovirus vectors OCT3/4, SOX2, KLF4, and c-MYC. Fibroblast iPSCs 2 1 False 24642446
Maetzel Niemann-Pick Type C NPC1/ I1061T Homo sapiens 2014 Lentiviruses encoding a polycistronic doxcycycline-inducible (DOX) for Oct4, Klf4, Sox2, c-Myc Fibroblast Neurons 4 2 True 24936472
Mazzulli Gaucher's Disease GBA1/ not specified Homo sapiens 2011 Retroviral pMIG vectors OCT4, SOX2, cMYC and KLF4 Fibroblast iPSCs, Neurons 2 3 False 21700325
Ananiev Rett Syndrome MeCP2/ R294X, MeCP2/ T158M, MeCP2/ V247X, MeCP2/R306C Homo sapiens 2011 Retroviral plasmids for OCT4, SOX2, KLF4 and c-MYC Fibroblast Neurons, iPSCs 1, 1, 1, 1 1 True 21966470
Panicker Gaucher's Disease GBA1/ L444P, GBA1/ N370S Homo sapiens 2012 Retroviral plasmids for OCT4, SOX2, KLF4 and c-MYC Fibroblast Neurons 2, 1 2 False 23071332
Krey Timothy Syndrome CACNA1C/ CaV1.2 Homo sapiens 2013 Retroviral transduction of Oct3/4, Sox2, c-MYC and Klf4 Fibroblast Neurons 2 2 False 23313911
Yoon Schizophrenia CYFIP1/ 15q11.2 Homo sapiens 2014 Sendai Viral Infection Fibroblast NSCs 3 3 False 24996170
Liu Alzheimer's Disease APP/ Duplication, PSEN1/A246E, PSEN1/H163R, PSEN1/M146L Homo sapiens 2014 Maloney Murine Leukemia Virus infection of Oct3/4,Sox2, Klf4, and c-Myc Fibroblast Neurons, NSCs, iPSCs 1, 2, 1, 1 2 False 25285942
Ren Parkinson's Disease Parkin/ Deletions on exons 3 and 5 Homo sapiens 2015 Lentiviruses expressing human Oct4, Sox2, Klf4, c-Myc and Nanog Fibroblast Neurons 2 2 False 25332110
Devlin Amyotrophic lateral sclerosis TDP-43/M337V, C9ORF72/ GGGGCC repeats Homo sapiens 2015 Lentivirus or Sendai vectors for OCT4, SOX2, KLF4 and c-MYC Fibroblast Neurons 1, 2 3 False 25580746
Liu Amyotrophic lateral sclerosis FUS/P525L Homo sapiens 2015 Nucleofected with 15–20 μg EVplasmid DNA using a human CD34+ Cell Nucleofector™ Kit Fibroblast Neurons 1 1 False 25912081
Lenzi Amyotrophic lateral sclerosis FUS/R514S, FUS/R521C, FUS/P525L Homo sapiens 2015 Lentiviral vector hSTEMCCA for OCT4, SOX2, KLF4 and c-MYC Fibroblast Neurons, iPSCs 1, 1, 1, 2 True 26035390
Ehrlich Frontotemporal dementia MAPT/ N279K, MAPT/ V337M Homo sapiens 2015 Lentiviral transduction with a polycistronic vector encoding OCT4,KLF4, SOX2, and C-MYC Fibroblast Neurons 1, 1 3 False 26143746
Liu Spinal Muscular Atrophy SMN1/ Deletion of exons 7 and 8 Homo sapiens 2015 Retrovirus for OCT4, SOX2, KLF-4 and c-MYC Fibroblast Neurons 3 3 False 26190808
Shcheglovitov Phelan-McDermid Syndrome SHANK3/ Deletion Homo sapiens 2013 Retroviruses carrying SOX2, OCT3/4, c-MYC and KLF4 transcription factors Fibroblast iPSCs, Neurons 2 2 False 24132240
Grima Huntington’s Disease HTT / 53 CAG repeats, HTT / 109 CAG repeats Homo sapiens 2017 Non-integrating episomal plasmids containing OCT4, SOX2, KLF4, L-MYC, LIN28, and p53 Fibroblast Neurons 1,1 1,1 False 28384479
Bidinosti Phelan-McDermid Syndrome SHANK3/ Deletions Homo sapiens 2016 Nonintegrating Sendai virus of OCT4, SOX2, KLF4 and c-MYC Fibroblast Neurons 2 2 False 26847545
Sivadasan Amyotrophic lateral sclerosis C9ORF72 / intronic GGGCC repeats Homo sapiens 2016 Retroviruses containing human Oct3/4, Sox2, Klf4, and c-Myc Fibroblast Neurons 2 2 False 27723745
Dickey Huntington’s Disease HTT / 60 CAG repeats Homo sapiens 2016 Lentiviral transduction of Oct4, Sox2, Klf4, cMyc, Nanog, and Lin28 Fibroblast Neurons 1 1 False 26642438
Orellana Pantothenate kinase-associated neurodegeneration PANK2 / c.1259delG, PANK2 / c.569insA Homo sapiens 2016 Nonintegrating Sendai virus of OCT4, SOX2, KLF4 and c-MYC Fibroblast NSCs, Neurons 2, 1 3, 3 False 27516453
Silva Frontotemporal dementia MAPT / A152T Homo sapiens 2016 Retroviral vector infection containing human Oct4, Sox2, Klf4, and c-Myc Fibroblast Neurons 2 2 False 27594585
Aflaki Gaucher Disease GBA1 / N370S, GBA1 / IVS2+1G>T; L444P Homo sapiens 2016 Cre-excisable polycistronic lentivirus encoding SOX2, KLF4, OCT4 and c-MYC Fibroblast NSCs, Neurons 4, 1 1, 1 False 27413154
Stanslowsky Chorea-Acanthocytosis VPS13A / c.4282G>C, VPS13A / c.7806G>A Homo sapiens 2016 Retroviral transduction of Oct4, c-MYC Sox2, Klf4 Fibroblast Neurons 1, 1 2, 2 False 27881786
Trilck Niemann-Pick disease Type C NPC1 / c.3182T>C, NPC1 / c.1836A>C/c.1628delC Homo sapiens 2017 Retroviral transduction of Oct4, c-MYC Sox2, Klf4 Fibroblast Neurons 1, 1 1, 1 False 27923633
Hallman Frontotemporal dementia MAPT / N279K Homo sapiens 2017 Lentiviral transduction with a polycistronic vector encoding OCT4,KLF4, SOX2, and C-MYC Fibroblast Neurons, Astrocytes 1 1 True 28256506
Vessoni Cockayne Syndrome ERCC6 / not specificied Homo sapiens 2016 Non-integrating Sendai vectors containing OCT4,KLF4, SOX2, and C-MYC Fibroblast Neurons 2 2 False 26755826
Francis Smith-Lemli-Opitz syndrome DHCR7 / p.M1V; p.Q98X, DHCR7 / p.T154M; c.964-1G>C, DHCR7 / p.T93M; c.964-1G>C, DHCR7 / c.964-1G>C Homo sapiens 2016 Lentiviral transduction with loxP-flanked STEMCCA polycistronic vector Fibroblast iPSCs 2,2,4,3 4,4,4,4 False GSE61203 Affymetrix Human Exon 1.0 ST Array GPL5175 26998835
Martinez Multisystem proteinopathy hnRNPA2/B1 / D290V, VCP / R155H Homo sapiens 2016 Nonintegrating Sendai virus of OCT4, SOX2, KLF4 and c-MYC Fibroblast Neurons 3, 2 1, 1 False GSE86464 Affymetrix Human Transcriptome Array 2.0 GPL17585 27773581
Yagi Alzheimer's Disease PSEN1/ A246E, PSEN2/ N141I Homo sapiens 2011 Retroviral transduction of OCT4, SOX2, KLF4, LIN28 and NANOG Fibroblast Neurons 1, 1 1 False GSE28450 Agilent-022060 GPL10123 21900357
Corti Spinal Muscular Atrophy SMN1/ not specified Homo sapiens 2012 oriP/EBNA1-based episomal vectors of OCT4, SOX2, NANOG, LIN28, c-Myc, and KLF4 by nucleofection Fibroblast Neurons 2 2 False GSE27206 HG-U133_Plus_2 GPL570 23253609
Ebert Spinal Muscular Atrophy SMN1/ not specified Homo sapiens 2009 Lentiviral infection of primers for OCT 4, SOX 2, NANOG, LIN 28, HoxB4, SMN, and GAPDH Fibroblast Neurons, Astrocytes 1 1 False GSE13828 HG-U133_Plus_2 GPL570  19098894
Liu Hutchinson-Gilford progeria syndrome LMNA/ point mutation Homo sapiens 2011 Retroviruses encoding OCT4, SOX2, KLF4, c-MYC, and GFP Fibroblast iPSCs 1 2 False GSE24487 HG-U133_Plus_2 GPL570  21346760
Liu Parkinson's Disease LRRK2/ G2019S Homo sapiens 2012 Retroviruses expressing OCT4, SOX2, KLF4 Fibroblast NSCs 2 1 False GSE34061 HiSeq 2000 GPL11154 23075850
Sareen Frontotemporal dementia/ Amyotrophic lateral sclerosis C9ORF72/ GGGGCC repeats Homo sapiens 2013 pCXLE-hUL, pCXLE-hSK, and pCXLE-hOCT3/4-shp53-F vectors Fibroblast Neurons, NSCs, Astrocytes 4 4 False GSE52202 HiSeq 2000 GPL11154 24154603
Kiskinis Amyotrophic lateral sclerosis SOD1/ A4V Homo sapiens 2014 Retroviral transduction of SOX2, OCT3/4, KLF4 and C-MYC Fibroblast Neurons 2 2 True GSE54409 HiSeq 2000 GPL11154 24704492
Woodard Parkinson's Disease GBA1/ N370S Homo sapiens 2014 Sendai virus of OCT4, SOX2, KLF4 and c-MYC Fibroblast Neurons 2 4 True GSE62642 HiSeq 2500 GPL16791 25456120
Kondo Alzheimer's Disease APP/ E693Δ, APP/ V717I, Sporadic/AD8K213 Homo sapiens 2013 Human complementary DNA by episomal vectors Fibroblast Neurons, Astrocytes 3, 2, 2 3 False GSE43326 HuGene-1_0-st GPL6244 23434393
Marchetto Rett Syndrome MeCP2/ Q244X Homo sapiens 2010 Retrovirus vectors containing the Oct4, c-Myc, Klf4 and Sox2  Fibroblast Neurons 4 5 False GSE21037 HuGene-1_0-st GPL6244 21074045
HD iPSC Consortium Huntington's Disease HTT/ CAG repeats Homo sapiens 2012 Lentiviral transduction of Oct4, Sox2, Klf4, cMyc, Nanog and Lin28 Fibroblast Neurons, NSCs 2 2 False GSE37517 HuGene-1_0-st GPL10739 22748968
Andrade Cockayne syndrome ERCC6/ not specified Homo sapiens 2012 pMXs retroviral vectors containing the human cDNA for c-Myc, Klf4, Oct3/4, Sox2 VSGV and CMVgp Fibroblast Neurons, iPSCs 1 2 False GSE36648 HuGene-1_0-st GPL6244 22661500
Devine Parkinson's Disease SNCA/ Triplication Homo sapiens 2011 pMXs-cMyc #13375, pMXs-Klf4 #13370, pMXs-Oct4 #13366, pMXs-Sox2 #13367 reprogramming factors from Addgene Fibroblast Neurons 1 1 False GSE28366 HumanOmni1-Quad GPL8882 21863007
HD iPSC Consortium Huntington’s Disease HTT / 46 CAG repeats, HTT / 53 CAG repeats, HTT / 109 CAG repeats Homo sapiens 2017 Non-integrating episomal plasmids containing OCT4, SOX2, KLF4, L-MYC, LIN28, and p53 Fibroblast Neurons 2,2,2 4,4,4 False GSE95344 Illumina HiSeq 2000) GPL11154 28319609
Sherman Friedreich's Ataxia FXN/ Long GAA⋅TTC repeats Homo sapiens 2010 VSV-G Retrovirus vectors for Oct3/4, Sox2, Klf4, and c-Myc Fibroblast iPSCs 2 1 False GSE22651 Illumina HumanHT-12 V3.0 GPL6947  21040903
Efthymiou Niemann-Pick Type C PLP1/ I1061T Homo sapiens 2015 STEMCCA lentivirus system Fibroblast Neurons 1 1 False GSE55379 Illumina HumanHT-12 V4.0 GPL10558 25637190
Ryan Parkinson's Disease SNCA/ A53T Homo sapiens 2013 Retroviruses of OCT4, KLF4, SOX2, and c-MYC Fibroblast Neurons 2 1 False GSE46798 Illumina HumanHT-12 v4 GPL10558 24290359
Pasca Timothy Syndrome CACNA1C/ CaV1.2 Homo sapiens 2012 Retroviruses expressing SOX2, OCT3/4, KLF4 and C-MYC Fibroblast Neurons 2 3 False GSE25542 Illumina HumanRef-8 v3.0 GPL6883 22120178
Lafaille Childhood HSE UNC-93-B/ not specified, TLR3/ not specified Homo sapiens 2012 Polycistronic lentiviral pHAGE–STEMCCA–LoxP vector, carrying the OCT4, SOX2, KLF4, and C-MYC reprogramming factor genes Fibroblast Neurons, NSCs, Astrocytes, Oligodendrocytes 1, 1 1 False GSE40593 Illumina HumanWG-6 v3.0 GPL6884 23103873
Wen Schizophrenia/ Major Depressive Disorder DISC1/ 4bp C-terminus deletion Homo sapiens 2014 Non-integrating EBV-based vector transfection Fibroblast Neurons 2 3 True GSE57821 Ion Torrent Proton GPL17303 25132547
An Huntington's Disease HTT/ CAG repeats Homo sapiens 2012 VSVg retroviruses of Sox2, Klf4, Oct3/4, and/or c-Myc Fibroblast NSCs 1 1 False GSE37547 Nimblegen Homo sapiens HG18 (12x135k)  GPL15338  22748967
Jiang Parkinson's Disease Parkin/ Deletions on exons 3 and 5 Homo sapiens 2012 FUW-tetO-LoxP lentiviruses: hOct4, hSox4, hKlf4 and hNanog Fibroblast Neurons 2 2 False GSE35190 RPCI Human HB21K GPL15098 22314364
Reinhardt Parkinson's Disease LRRK2/ G2019S Homo sapiens 2013 Retroviruses containing human Oct3/4, Sox2, Klf4, and c-Myc Fibroblast Neurons 2 4 False GSE43364 illumina HumanHT-12 v4 GPL10558 23472874
Almeida Frontotemporal dementia  PGRN/ S116X Homo sapiens 2012 Retroviruses encoding human OCT3/4, SOX2, KLF4, and c-MYC Fibroblast Neurons 1 1 False GSE40378 illumina HumanHT-12 v4 GPL10558 23063362